How does a cell manage to differential and degrade the diverse types of defective proteins and thus protect the body against serious diseases? The researchers Sabine C. Horn, instructor Thomas Sommer, monitor Udo Heinemann and Dr. Ernst Jarosch of the Max Delbrück Center for Molecular inoculation (MDC) Berlin-Buch, Germany, have now found a crucial piece in this puzzle. In an enzyme complex that plays a critical role in the quality control of proteins, they discovered a scaffold regulating the identification and bartering of various defectively produced proteins. (Molecular Cell, doi: 10.1016/j...

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