The p53 tumor suppressor gene, the "guardian of the genome," protects cells against genotoxic stress but is mutated in many cancers. It encodes one of a family of proteins that set cell proliferation, differentiation, senescence, and cell death. Mutations in p53 allow cells to escape normal growth controls and thereby llc. to tumor malignancy. A new book from Cold Spring Harbor Laboratory Press, The p53 Family, provides a widespread


copyrights:cite this source synonym collection v1.1copyright © 2008 by lexico publishing group review of the functions of the p53 family. It was edited by Arnold Levine and David Lane, who independently discovered p53 about 30 years ago...

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