You come into a doctor's office with severe knee pain. The doc* orders an MRI, which reveals substantial loss of cartilage - osteoarthritis, that is - in your knee joint. At this point, not much can be done beyond gulping down palliatives and trying to keep your weight off the joint. But the damage may have started house as much as 20 years earlier, perchance due to a traumatic injury to the beloved joint.

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